Viagra for heart failure

Author: darkAddisonextra | 2024-08-15 23:32:17

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Compounds related to Viagra, which is already in clinical trials to prevent heart failure, may also counter the disease in a different way, according to a study published online today in the journal Circulation Research. The results hold promise for the design of a new drug class and for its potential use in combination with Viagra or beta blockers.In heart failure, which affects about 5.7 million Americans, the heart gradually loses the ability to pump with enough force to supply the body with blood. One reason for lost pumping strength is the mass death of heart muscle cells seen in many heart diseases (e.g. heart attack). Fewer remaining muscle cells must then push around the same amount of blood, and hard working muscles grow. Unlike the healthy bulging of an athlete's bicep, abnormal muscle growth (pathogenic hypertrophy) in diseased hearts thickens chamber walls, slows the heartbeat and causes potentially fatal arrhythmias. Hypertrophy is a major risk factor for the development of heart failure as well.Recent efforts to reverse hypertrophy include a clinical trial, sponsored by Viagra manufacturer Pfizer, and the National Heart, Lung, and Blood Institute (NHLBI), looking at whether Viagra (sildenafil) can treat moderate heart failure and reduce hypertrophy. Along with increasing blood flow in arteries, Viagra interferes with phosphodiesterases (PDEs), enzymes that break down the messenger molecule called cyclic guanosine monophosphate (cGMP), which would otherwise "put the brakes on" heart muscle cell growth.Viagra shuts down the PDE5 family in particular, one of 11 PDE families in the body and that include more than 50 individual enzymes. They have proven to be famously good drug targets because each has a unique structure, tissue distribution and role, allowing them to be precisely targeted by drugs for fewer side effects. In the just-published experiments in heart muscle cells and live mice, researchers found that members of a second PDE family, particularly the PDE1a enzyme, also break up cGMP to control hypertrophy, but not in the same way as Viagra.Where PDE5 breaks down cyclic nucleotides in response to the vital signaling molecule nitric oxide (NO), PDE1 affects cyclic nucleotide pathways sensitive to

Cardiac Drug and Supplement Information - LeadER Vet

• Aim: The 2025 AHA/ACC/HFSA Guideline for the Management of Heart Failure replaces the 2025 ACCF/AHA Guideline for the Management of Heart Failure and the 2025 ACC/AHA/HFSA Focused Update of the 2025 ACCF/AHA Guideline for the Management of Heart Failure. The 2025 guideline is intended to provide patient-centric recommendations for
• Background Erectile dysfunction (ED) is common in patients with congestive heart failure (CHF) and is often associated with symptoms of depression. Although sildenafil citrate, a phosphodiesterase 5 inhibitor, is effective in treating ED, its use is considered a relative contraindication in
• Back to Sildenafil (Viagra) Who can and cannot take sildenafil Who can take sildenafil. Most men aged 18 and over can take sildenafil for erectile dysfunction. heart attack or a heart problem – your doctor should carefully check whether your heart can take the additional strain of having sex; have low blood pressure (hypotension)

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Viagra could prevent heart attacks, according to research.Patients taking the male impotence drug were found to have a lower risk of having a heart attack or dying from heart failure than those not on the medication.The lead scientist told the Daily Express the findings are "incredibly exciting".Experts from the Centre for Cardiac Research at the University of Manchester studied 6000 diabetic patients in Cheshire who had been given Viagra - which works by increasing blood flow - to treat erectile dysfunction.Despite diabetics being prone to heart problems, the study participants did not suffer as many incidents as similar patients not on the drug.Professor Andrew Trafford and his team, funded by the British Heart Foundation, are hoping to show the medication can also help prevent arrhythmias - abnormal heart rhythms.He said: "Heart failure is a devastating condition which means your heart is not pumping blood around your body as well as it used to. It can really impact a person's quality of life and currently the outlook for patients with heart failure is grim - worse than that of some cancers."Our studies have shown that drugs normally used for the treatment of erectile dysfunction, such as Viagra, actually have a very pronounced effect in slowing the progression of heart failure as well as reducing the likelihood of fatal arrhythmias.He added: "We have recently established that patients who receive Viagra or similar drugs for erectile dysfunction are also far less likely to then go on and die from a heart attack."

Viagra protects the heart beyond the bedroom, study finds

Viagra for heart failure	darkAddisonextra	'Viagra' for women: Types, how they work, and side effects
Erectile dysfunction Causes, Symptoms Treatment -Clicks	(4.3 / 2441 reviews)	Heart failure or dyspnea: 34% for sildenafil vs. 20% for placebo (p = 0.04) Interpretation: Among patients with persistent pulmonary hypertension after valve replacement or repair (majority mitral another valve), the use of sildenafil was not beneficial. Sildenafil was associated with unfavorable clinical outcomes compared with placebo.

Viagra Boosts Heart Performance And May Save Lives, Study

Viagra, the little blue pill that’s improved the sex lives of millions, has warmed hearts worldwide given its success in the bedroom. But it may do more than bring hearts together – it may improve heart health, according to a study published in the journal BMC Medicine. That’s because, as the study showed in men with varying degrees of heart failure, Viagra improved how well the heart pumped blood and reduced thickness of heart muscle on the heart’s left ventricle, the part that does the most pumping. This thickening often is caused by high blood pressure and results in heart failure and angina. So, yes, reducing that thickness would be a good thing, according to Marshfield Clinic cardiologists. Next steps “It’s an interesting study, but the next step is a large, randomized clinical trial,” said Dr. Sanjay Kumar, a Marshfield Clinic cardiologist who specializes in electrophysiology or the heart’s electrical system. “We have much research to do before we can conclusively say who, if anyone, would benefit from such a treatment for heart failure.” Viagra, or sildenafil citrate, works by blocking an enzyme called PDE5. This enzyme prevents smooth muscle, found mostly in the penis and lungs, from relaxing. When Viagra goes to work, the muscle relaxes, allowing blood to flow easily. For years doctors have used sildenafil citrate to treat high blood pressure that affects the lungs, allowing for better blood flow. Now, as in this study, they’re finding this enzyme that prevents relaxation is common in heart failure

This subreddit is dedicated to all things involved with surviving and living with the constraints of heart failure. We are a community dedicated to support; sharing of experiences, resources, and tips; and fostering safe relationships, with emphasis on heart failure. Id hate to take viagra and then find myself dependent on it for actual A Viagra-like drug could reverse heart failure: Media name/outlet: Medical News Today: Media type: Web: Country/Territory: United Kingdom: Date: : Description: New research in sheep shows that a drug that doctors usually prescribe for the treatment of erectile dysfunction can also treat heart failure. URL: