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119.9, 121.8, 126.4, 134.5, 136.8, 137.6, 146.7, 147.6, 167.1, 167.5………………………………………………………….Synthesis pathwayTrade NamesCountryTrade nameManufacturerGermanyCialisLillyFranceCialis– “-United Kingdom– “-– “-Italy– “-Eli LillyUSA– “-Lilly ICOSUkraineCialisLilly del Caribe, Inc.., Puerto Rico (USA) Lilly SA (Packing), SpainTadalafilAurohem Laboratories Pvt. Ltd.., IndiaFormulationsTablets 10 mg, 20 mgLinksEP 740 668 (Lab. Glaxo SA, Fr .; GB -prior. 21.01.1994).US 6,140,329 (Lab. Glaxo SA, Fr .; GB -prior. 14/07/1995).US 6,143,746 (Icos Corp .; 07/11/2001; GB -prior. 01.21.1994).US 6,821,975 (Lilly ICOS; 23.11.2004; appl. 19.7.2002; USA-prior. 3.8.1999).US 6,943,166 (Lilly ICOS; 13.9.2005; appl. 19.10.2001; USA-prior. 30.4.1999).US 7,182,958 (Lilly ICOS; 27.2.2007; appl. 26.4.2000; USA-prior. 3.8.1999).References Daugan, A; Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R (October 9, 2003). “The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1′,5′:1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues”. Journal of Medicinal Chemistry 46 (21): 4525–32. doi:10.1021/jm030056e . PMID 14521414. Richards, Rhonda (September 17, 1991). “ICOS At A Crest On Roller Coaster”. USA Today. p. 3B. Ervin, Keith (June 21, 1998). “Deep Pockets + Intense Research + Total Control = The Formula — Bothell Biotech Icos Keeps The Pipeline Full Of Promise”. The Seattle Times. p. F1. Retrieved January 10, 2009. Revill, Jo (February 2, 2003). “Drugs giant says its new pill will pack more punch than rival Viagra”. The Observer. Retrieved 2007-04-06. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm274642.htm https://www.consumerreports.org/health/resources/pdf/best-buy-drugs/money-saving-guides/english/PillSplitting-FINAL.pdf “FDA Announces Revisions to Labels for Cialis, Levitra and Viagra”. Food and Drug Administration. 2007-10-18. Retrieved 2009-09-28. “Cialis: Warnings, Precautions, Pregnancy, Nursing, Abuse”. RxList. 2007. Retrieved 2007-04-06. Bischoff, E (June 2004). “Potency, selectivity, and consequences of nonselectivity of

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